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Genes, Vol. 10, Pages 915: Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
Skalnikova National cancer databases document that melanoma is the most aggressive and deadly cutaneous malignancy with worldwide increasing incidence in the Caucasian population. Around 10% of melanomas occur in families. Several germline mutations were identified that might help to indicate individuals at risk for preventive interventions and early disease detection. More than 50% of sporadic melanomas carry mutations in Ras/Raf/mitogen-activated protein kinase (MAPK/MEK) pathway, which may represent aims of novel targeted therapies. Despite advances in targeted therapies and immunotherapies, the outcomes in metasta...
Source: Genes - November 8, 2019 Category: Genetics & Stem Cells Authors: Vratislav Horak Anna Palanova Jana Cizkova Veronika Miltrova Petr Vodicka Helena Kupcova Skalnikova Tags: Review Source Type: research

Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine.
In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melan...
Source: Experimental and Molecular Pathology - November 13, 2013 Category: Pathology Authors: Trowbridge RM, Mitkov MV, Hunter WJ, Agrawal DK Tags: Exp Mol Pathol Source Type: research

Sensors, Vol. 19, Pages 2815: Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model
In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation.
Source: Sensors - June 23, 2019 Category: Biotechnology Authors: Karl Kratkiewicz Rayyan Manwar Ali Rajabi-Estarabadi Joseph Fakhoury Jurgita Meiliute Steven Daveluy Darius Mehregan Kamran (Mohammad) Avanaki Tags: Article Source Type: research

Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-kappaB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
Conclusions: It indicates that CSFV can be recognized by both RIG-I and MDA5 to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
Source: Virology Journal - September 13, 2013 Category: Virology Authors: Xiao-Ying DongWen-Jun LiuMing-Qiu ZhaoJia-Ying WangJing-Jing PeiYong-Wen LuoChun-Mei JuJin-Ding Chen Source Type: research

Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-¿B activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
Conclusions: It indicates that CSFV can be recognized by both RIG-I and MDA5 to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
Source: Virology Journal - September 13, 2013 Category: Virology Authors: Xiao-Ying DongWen-Jun LiuMing-Qiu ZhaoJia-Ying WangJing-Jing PeiYong-Wen LuoChun-Mei JuJin-Ding Chen Source Type: research

The role of αβ T-cells in spontaneous regression of melanoma tumors in swine.
Abstract Using a porcine model, we describe Melanoma-Associated CD4+CD8hi T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4+CD8hi phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4+CD8hi TIL have a similar expression of selected markers indicating that they represent effector/memory αβ T-cell subset. Moreover, although TIL also contain CD4-CD8+ T-cells, only CD4+CD8hi TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different mel...
Source: Developmental and Comparative Immunology - October 8, 2018 Category: Allergy & Immunology Authors: Cizkova J, Sinkorova Z, Strnadova K, Cervinkova M, Horak V, Sinkora J, Stepanova K, Sinkora M Tags: Dev Comp Immunol Source Type: research

Antiviral Role of Serine Incorporator 5 (SERINC5) Proteins in Classical Swine Fever Virus Infection
In this study, overexpression of SERINC5 in PK-15 and 3D4/2 cells significantly inhibited the growth of CSFV, whereas SERINC5 silencing enhanced CSFV growth. Additionally, CSFV infection reduced SERINC5 production in cells and tissues. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify and analyze protein and peptide molecules that potentially interact with SERINC5. A total of 33 cellular protein candidates were identified. Next, SERINC5 was shown to interact with melanoma differentiation-associated protein 5 (MDA5) by yeast two-hybrid, protein co-localization and co-immunoprecipitation assays. ...
Source: Frontiers in Microbiology - September 3, 2020 Category: Microbiology Source Type: research

Spontaneous Regression of Swine Melanoma: The Role of Tumour-infiltrating T and NK Cells
CONCLUSION: Cytotoxic T cells were the most abundant population of tumour infiltrating immune cells found in MeLiM melanomas of animals aged 10-32 weeks, probably causing the destruction of melanoma cells. Furthermore, the development of specific (adaptive) immune response represented mainly by cytotoxic T cells seems to be crucial for the successful SR of porcine melanoma.PMID:36697105 | DOI:10.21873/anticanres.16199
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Daniela Planska Vratislav Horak Source Type: research

What Do Germans Want to Know About Skin Cancer? A Nationwide Google Search Analysis From 2013 to 2017
Conclusions: Our study provides insight into terms and fields of interest related to skin cancer relevant to the German population. Furthermore, temporal trends and courses are shown. This information could aid in the development and implementation of effective and sustainable awareness campaigns by developing information sources targeted to the population’s broad interest or by implementing new Internet campaigns.
Source: Journal of Medical Internet Research - May 2, 2018 Category: General Medicine Authors: Stefanie Seidl Barbara Schuster Melvin R üth Tilo Biedermann Alexander Zink Source Type: research

Web search data as health data? : Geographic differences, temporal trends, and topics of interest from internet search engine analyses in Germany
CONCLUSION: Web search data, given the limitations noted, are able to directly provide spatiotemporal mapping regarding the needs of the Internet-using population. They are particularly useful in situations where traditional health data are limited or unavailable.PMID:34812913 | PMC:PMC8609262 | DOI:10.1007/s00105-021-04918-x
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - November 23, 2021 Category: Dermatology Authors: S Ziehfreund L Tizek A Zink Source Type: research

Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.
CONCLUSIONS: The gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers. IMPLICATIONS: The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for thei...
Source: Journal of the Medical Library Association : JMLA - January 4, 2015 Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research

Interest in Skin Cancer in Urban Populations: A Retrospective Analysis of Google Search Terms in Nine Large German Cities.
Abstract Skin cancer is a major public health issue, which could be reduced through prevention programmes. However, prevention utilization is not very prevalent. It is therefore important to understand individuals' interest in skin cancer. Google AdWords Keyword Planner was used to identify the search volume in 9 German cities between July 2014 and June 2018. From a total of 1,203 identified keywords, 1,047 search terms were related to skin cancer, which had an overall search volume of 3,460,980. Most terms referred to "identifying skin cancer". For melanoma, the number of Google searches per 100,000 inhabitants c...
Source: Acta Dermato-Venereologica - May 9, 2019 Category: Dermatology Authors: Tizek L, Schielein MC, Rüth M, Szeimies RM, Philipp-Dormston WG, Braun SA, Hecker C, Eberlein B, Biedermann T, Zink A Tags: Acta Derm Venereol Source Type: research

Understanding Visual Search Patterns of Dermatologists Assessing Pigmented Skin Lesions Before and After Online Training
Abstract The goal of this investigation was to explore the feasibility of characterizing the visual search characteristics of dermatologists evaluating images corresponding to single pigmented skin lesions (PSLs) (close-ups and dermoscopy) as a venue to improve training programs for dermoscopy. Two Board-certified dermatologists and two dermatology residents participated in a phased study. In phase I, they viewed a series of 20 PSL cases ranging from benign nevi to melanoma. The close-up and dermoscopy images of the PSL were evaluated sequentially and rated individually as benign or malignant, while eye position ...
Source: Journal of Digital Imaging - November 7, 2014 Category: Radiology Source Type: research

Bio-guided search of active indole alkaloids from Tabernaemontana catharinensis: Antitumour activity, toxicity in silico and molecular modelling studies.
Abstract Active plant metabolites have been used as prototype drugs. In this context, Tabernaemontana catharinensis (Apocynaceae) has been highlighted because of the presence of active indole alkaloids. Thus, this study aims the bio-guided search of T. catharinensis cytotoxic alkaloids. The chemical composition was identified by high-resolution mass spectrometry, and fractionation was performed by open column and preparative thin-layer chromatography, from plant stems. The enriched fractions were tested in vitro in tumour cells A375 (melanoma cell line) and A549 (adenocarcinomic human alveolar basal epithelial cel...
Source: Bioorganic Chemistry - December 15, 2018 Category: Chemistry Authors: Rosales PF, Marinho FF, Gower A, Chiarello M, Canci B, Roesch-Ely M, Paula FR, Moura S Tags: Bioorg Chem Source Type: research

Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma.
Authors: Shevchenko VE, Kovalev SV, Arnotskaya NE, Zborovskaya IB, Akhmedov BB, Polotskii BE, Kostin AU, Moukeria AF, Zaridze DG, Davidov MI Abstract Blood plasma proteomes obtained from 77 lung squamous cell carcinoma (LSCC) patients (Stages I-III) and 67 healthy controls (all males) were analyzed by using the label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the search of potential cancer biomarkers. All plasma samples were depleted of 14 highly-abundant plasma proteins by immune-affinity column chromatography before LC-MS/MS. We identified and quantified 809 differential proteins wi...
Source: European Journal of Mass Spectrometry - December 1, 2014 Category: Chemistry Tags: Eur J Mass Spectrom (Chichester, Eng) Source Type: research